Chignen Possi, Kelvine published the artcileInfluences of histidine-1 and azaphenylalanine-4 on the affinity, anti-inflammatory, and antiangiogenic activities of azapeptide cluster of differentiation 36 receptor modulators, Application of H-Lys(Boc)-OH, the publication is Journal of Medicinal Chemistry (2017), 60(22), 9263-9274, database is CAplus and MEDLINE.
Azapeptide analogs of growth hormone releasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the cluster of differentiation 36 receptor (CD36). For example, [A1, azaF4] and [azaY4]-GHRP-6 were previously shown to bind selectively to CD36 and exhibited resp. significant antiangiogenic and slight angiogenic activities in a microvascular sprouting assay using choroid explants. The influences of the 1- and 4-position residues on the affinity, anti-inflammatory, and antiangiogenic activity of these azapeptides have now been studied in detail by the synthesis and anal. of a set of 25 analogs featuring Ala1 or His1 and a variety of aromatic side chains at the aza-amino acid residue in the 4-position. Although their binding affinities differed only by a factor of 17, the analogs exhibited significant differences in ability to modulate production of nitric oxide (NO) in macrophages and choroidal neovascularization.
Journal of Medicinal Chemistry published new progress about 2418-95-3. 2418-95-3 belongs to amides-buliding-blocks, auxiliary class Chiral,Carboxylic acid,Amine,Aliphatic hydrocarbon chain,Ester,Amino acide derivatives, name is H-Lys(Boc)-OH, and the molecular formula is C11H22N2O4, Application of H-Lys(Boc)-OH.
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