Badalanloo, Kimia published the artcileCytotoxic and Apoptotic Effects of Celecoxib and Topotecan on AGS and HEK 293 Cell Lines, Category: amides-buliding-blocks, the publication is Journal of Gastrointestinal Cancer (2022), 53(1), 99-104, database is CAplus and MEDLINE.
Abstract: Purpose: This study is aimed to assess the anti-cancer effects of Celecoxib and topotecan against Human Gastric cancer cell line (AGS) in comparison to the control in an in-vitro study. Methods: In this exptl. study, Celecoxib and topotecan was prepared at concentrations of 500, 250, 125, 62.5, 31.2, 15.6 and 7.8 mg/mL. The effect of celecoxib and topotecan sep. and in mixed form were investigated on AGS and normal HEK cells. To investigate the cell survival, MTT method was used to study the pathway of apoptosis using flowcytometry and Caspase kits based on colorimetric. Finally, one-way ANOVA and t-test were used to analyze the data. Results: The results of this study indicated that Celecoxib was cytotoxic against AGS and HEK cell lines. The topotecan indicated a significant cytotoxicity against AGS cells and was not toxic against HEK cell line. Our results indicated that Celecoxib and topotecan have synergist effects against AGS and HEK cell lines and were more effective than sep. celecoxib or topotecan. Conclusion: The mixture of clecoxib and topotecan was more effective than celecoxib and topotecan in sep. form. Our results indicated that use mixed forms of treatments can cause excellent therapeutic effects and can cause less side effects.
Journal of Gastrointestinal Cancer published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, Category: amides-buliding-blocks.
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https://en.wikipedia.org/wiki/Amide,
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