Ahmed, Ahmed A. M. published the artcileNew bis(pyrazolo[3,4-b]pyridines) and bis(thieno[2,3-b]pyridines) as potential acetylcholinesterase inhibitors: synthesis, in vitro and SwissADME prediction study, Category: amides-buliding-blocks, the publication is Journal of the Iranian Chemical Society, database is CAplus.
The bis(pyridine-2(1H)-thione) was prepared and taken as a key synthon of this study. The target bis(pyrazolo[3,4-b]pyridines) was prepared in good yields, by the reaction of bis(pyridine-2(1H)-thione) with appropriate hydrazonyl chlorides to yield bis(hydrazonothioates) followed by their heating in ethanolic sodium ethoxide solution Addnl., bis(pyridine-2(1H)-thione) reacted with different α-halogenated reagents to afford a new series of bis(thieno[2,3-b]pyridines), in good to excellent yields. In general, the tested series of bis(thieno[2,3-b]pyridines) demonstrated greater acetylcholinesterase inhibitory activity as well as DPPH antioxidant activity than the other series of (pyrazolo[3,4-b]pyridines). At a concentration of 100 μM, bis(thieno[2,3-b]pyridine-2-carbonitrile) showed the best acetylcholinesterase inhibitory activity with inhibition percentage of 83.2. In addition, the previous hybrid had the highest DPPH antioxidant activity, with an inhibition percentage of 82.6 when tested at a concentration of 25 μg/mL. Furthermore, SwissADME was used to predict the physicochem. properties, lipophilicity, and drug likeness of the new products.
Journal of the Iranian Chemical Society published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Category: amides-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics