Zheng, Deqiang’s team published research in Zhongguo Yiyao Gongye Zazhi in 47 | CAS: 1019206-88-2

Zhongguo Yiyao Gongye Zazhi published new progress about 1019206-88-2. 1019206-88-2 belongs to amides-buliding-blocks, auxiliary class Protein Tyrosine Kinase/RTK,VEGFR, name is 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrate, and the molecular formula is C15H14O3, Synthetic Route of 1019206-88-2.

Zheng, Deqiang published the artcileSynthesis of regorafenib, Synthetic Route of 1019206-88-2, the publication is Zhongguo Yiyao Gongye Zazhi (2016), 47(5), 528-530, database is CAplus.

Regorafenib was synthesized from 3-fluoro-4-nitrophenol (2) via reduction nitro group, nucleophilic substitution with N-methyl-4-chloropyridine-2-carboxamide (5), condensation with 4-chloro-3-(trifluoromethyl) Ph isocyanate (8), and then recrystallization by salt formation and neutralization with an overall yield of 63.8% (based on 2).

Zhongguo Yiyao Gongye Zazhi published new progress about 1019206-88-2. 1019206-88-2 belongs to amides-buliding-blocks, auxiliary class Protein Tyrosine Kinase/RTK,VEGFR, name is 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide hydrate, and the molecular formula is C15H14O3, Synthetic Route of 1019206-88-2.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics