Zhao, Lulu published the artcileElectrochemical Synthesis of β-Functionalized Ketones via Ring-Opening of Cycloalkanols, SDS of cas: 169590-42-5, the publication is Organic Letters (2022), 24(24), 4421-4426, database is CAplus and MEDLINE.
The electrochem. deconstructive functionalization of cycloalkanols with nucleophiles was studied, which allowed functionalization to occur exclusively at the β-position of ketones. The substrate scope includes a wide range of cycloalkanols as well as diverse N, O, C and P-centered nucleophiles, providing ready access to β-functionalized ketones as products. Mechanistic studies support the generation of α,β-unsaturated ketones as key intermediates followed by Michael addition with nucleophiles.
Organic Letters published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C13H10F2, SDS of cas: 169590-42-5.
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