Ohishi, Mitsuru published the artcileSacubitril/valsartan-A new weapon for fighting the hypertension paradox, HPLC of Formula: 137862-53-4, the publication is Hypertension Research (2022), 45(5), 915-916, database is CAplus and MEDLINE.
The estimated prevalence of hypertension in Japan is 43 million. However, when good blood pressure (BP) control is defined as <140/90 mmHg, only 12 million patients have achieved the targeted BP. Thus, 27% of individuals with hypertension have achieved satisfactory BP control. The guidelines for the management of hypertension by the Japanese Society of Hypertension (JSH2019) recommended that the antihypertensive target should be <130/80 mmHg, except in older individuals (≥75 years); individuals with cerebrovascular disease, with bilateral carotid artery stenosis or occlusion of the main cerebral artery; or individuals with chronic kidney disease without proteinuria. In the excluded groups, excessive antihypertensive treatments may increase adverse drug effects. Studies have shown that 21.6% of all patients with hypertension have achieved a BP <130/80 mmHg, and the control rate is lower among younger individuals. Sacubitril/valsartan is a new type of antihypertensive drug combination that contains a 1:1 molar ratio of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril. A recent phase III study assessed the efficacy and safety of sacubitril/valsartan vs. olmesartan in Japanese patients with mild-to-moderate essential hypertension. Strict BP control without giving up will make it possible to extend our healthy life expectancy by preventing stroke and cardiovascular diseases.
Hypertension Research published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, HPLC of Formula: 137862-53-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics