Misner, Jerry W.’s team published research in Journal of Organic Chemistry in 52 | CAS: 2451-91-4

Journal of Organic Chemistry published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Synthetic Route of 2451-91-4.

Misner, Jerry W. published the artcileAn improved method for the decyanation of N,N-disubstituted cyanamides, Synthetic Route of 2451-91-4, the publication is Journal of Organic Chemistry (1987), 52(14), 3166-8, database is CAplus.

The cleavage of N,N-disubstituted cyanamides, e.g. the ergoline I (R = cyano), to secondary amines, e.g. I (R = H), is effected rapidly and in high yields with NaOH or KOH in ethylene glycol at temperature greater than 120°. The products can usually be isolated easily as either the free amines or as their salts so long as they are reasonably hydrophobic. This procedure is an excellent alternative to other methods, especially with acid sensitive substrates.

Journal of Organic Chemistry published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Synthetic Route of 2451-91-4.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics