Gryszkiewicz-Trochimowski, E. published the artcileAmides of carboxylic acids of the heterocyclic series, Application of N,N-Diethylisonicotinamide, the publication is Roczniki Chemii (1931), 193-202;201-2 in French, database is CAplus.
In analogy with the N-diethylamide of 3-pyridinecarboxylic acid coramine, 3 new diethylamides were prepared, viz., of 2-pyridinecarboxylic, of 4-pyridinecarboxylic and of tetramethylpyrrolinecarboxylic acid, resp., and their chem. and physiol. properties were investigated. Picolinyl chloride (I) is prepared according to Meyer, Monatsh. 22, 112(1901), from the acid (II) and SOCl2. N-Diethylamide of II, prepared from pulverized (I) and dry Et2NH, almost odorless oil of bitter taste, neutral, m. 26-8°, b3 122.5-3°, corrected, d416.2 1.0603, nα16.2 1.5209, nD16.2 1.5254, nβ16.2 1.5348. Coramine, m. 21-3°, b3 128.5-9°, corrected, nα16.2 1.5235, nD16.2 1.5279, nβ16.2 1.5391. N-Diethylamide of 4-pyridinecarboxylic acid (isonicotinic acid), prepared similarly to II, is a neutral, viscous oil, m. 22-4°, b3 123-3.5°, corrected, d416.2 1.0630, nα16.2 1.5225, nD16.2 1.5269, nβ16.2 1.5380. N-Diethylamide of 2,2′,5,5′-tetramethylpyrrolinecarboxylic acid (III), prepared by interaction of dibromotriacetoneamine-HBr (prepared according to Pauly, Ber. 31, 672), and 33% aqueous Et2NH, m. 33-4°, b9 129.5-30°. It tastes bitter and reacts strongly alk. The 3 diethylamides differ in their physiol. action. The 2-isomer has an action on the heart similar to that of coramine, but does not affect the nervous system. The physiol. action of III is entirely different from that of coramine.
Roczniki Chemii published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Application of N,N-Diethylisonicotinamide.
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