Shim, Min Suk published the artcileA Reactive Oxygen Species (ROS)-Responsive Polymer for Safe, Efficient, and Targeted Gene Delivery in Cancer Cells, Synthetic Route of 1869-45-0, the publication is Angewandte Chemie, International Edition (2013), 52(27), 6926-6929, database is CAplus and MEDLINE.
Thioketal-based I was prepared for targeted gene delivery in prostate cancer. Degradation of thioketal linkages in I under reactive oxygen species conditions led to efficient intracellular release of the complexed DNA in prostate cancer cells. The DNA-I polyplexes exhibited efficient gene transfection. Incorporation of GRP78-binding peptide into I achieved cancer-targeted gene transfection.
Angewandte Chemie, International Edition published new progress about 1869-45-0. 1869-45-0 belongs to amides-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is 2,2,2-Trifluoro-N-(2-mercaptoethyl)acetamide, and the molecular formula is C10H14N2O, Synthetic Route of 1869-45-0.
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https://en.wikipedia.org/wiki/Amide,
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