Maddaloni, Ernesto published the artcileHigh density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes, HPLC of Formula: 321673-30-7, the publication is Cardiovascular Diabetology (2017), 116/1-116/11, database is CAplus and MEDLINE.
Background: Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes (T1D). A pro-calcific drift of circulating monocytes has been linked to vascular calcification and is marked by the surface expression of osteocalcin (OCN). We studied OCN + monocytes in a unique population with ≥50 years of T1D, the 50-Yr Joslin Medalists (J50M). Methods: CD45 bright/CD14 + /OCN + cells in the circulating mononuclear blood cell fraction were quantified by flow cytometry and reported as percentage of CD45 bright cells. Mechanisms were studied by inducing OCN expression in human monocytes in vitro. Results: Subjects without history of CVD (n = 16) showed lower levels of OCN + monocytes than subjects with CVD (n = 14) (13.1 α 8.4% vs 19.9 α 6.4%, p = 0.02). OCN + monocytes level was inversely related to total high d. lipoprotein (HDL) cholesterol levels (r = -0.424, p = 0.02), large (r = -0.413, p = 0.02) and intermediate (r = -0.445, p = 0.01) HDL sub-fractions, but not to small HDL. In vitro, incubation with OxLDL significantly increased the number of OCN + monocytes (p < 0.01). This action of OxLDL was significantly reduced by the addition of HDL in a concentration dependent manner (p < 0.001). Inhibition of the scavenger receptor B1 reduced the effects of both OxLDL and HDL (p < 0.05). Conclusions: Low OCN + monocytes levels are associated with lack of CVD in people with long duration T1D. A possible mechanism for the increased OCN + monocytes could be the elevated levels of oxidized lipids due to diabetes which may be inhibited by HDL. These findings suggest that circulating OCN + monocytes could be a marker for vascular disease in diabetic patients and possibly modified by HDL elevation.
Cardiovascular Diabetology published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, HPLC of Formula: 321673-30-7.
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