Lai, Huifang published the artcileCopper-promoted direct amidation of isoindolinone scaffolds by sodium persulfate, Formula: C2H4ClNO, the publication is Organic & Biomolecular Chemistry (2021), 19(35), 7621-7626, database is CAplus and MEDLINE.
Isoindolinones are ubiquitous structural motifs in natural products and pharmaceuticals. Establishing an efficient method for structural modification of isoindolinones could significantly facilitate new drug development. Herein, authors describe copper-promoted direct amidation of isoindolinone scaffolds mediated by sodium persulfate. The method exhibits mild reaction conditions and high site-selectivity, and enables the structural modification of the drug indobufen ester with various amides with yields of 49 to 98%. It is also gram-scalable. Addnl., the reaction mechanism appears to involve a radical and a carbocationic pathway.
Organic & Biomolecular Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Formula: C2H4ClNO.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics