Khairullina, V. R. published the artcileStructural Analysis of Leukotriene B4 (LBT4) Receptor (BLT1 AND BLT2) Antagonists, Application of [(2-Hexylcyclopentylidene)amino]thiourea, the publication is Pharmaceutical Chemistry Journal (2014), 48(5), 317-322, database is CAplus.
The structural characteristics typical of highly and moderately effective antagonists of BLT1 and BLT2 receptors were identified and the extents of their influences on the target property were evaluated. Two models for predicting inhibitory activity were constructed for series of sulfur-, nitrogen- and oxygen-containing heterocyclic compounds with significant prognostic levels of greater than 80% using two methods based on sample recognition theory. These structural patterns can be used for virtual screening of potential drugs for antiallergic activity associated with blockade of leukotriene LTB4-sensitive BLT1 and BLT2 receptors.
Pharmaceutical Chemistry Journal published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C12H23N3S, Application of [(2-Hexylcyclopentylidene)amino]thiourea.
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