Hirai, Kentaro published the artcileStudies on heterocyclic cation systems. XI. Syntheses of 2-disubstituted-amino-4-arylthiazol-5-ylalkanoic acids, COA of Formula: C5H10N2OS, the publication is Chemical & Pharmaceutical Bulletin (1977), 25(9), 2292-9, database is CAplus.
2-Disubstituted-amino-4-arylthiazol-5-ylalkanoic acids I (R = piperidino, morpholino, MeNH, BzNH, p-ClC6H4CONH, R1 = H, Me; R2 = Ph, 2-thienyl, p-ClC6H4, p-BrC6H4) were prepared Thus, dehydration of S-(α-benzoyl-β-ethoxycarbonyl)ethyl 1-piperidinethiocarbonate in the presence of aqueous HClO4-Ac2O yielded 4-ethoxycarbonylmethyl-5-phenyl-2-piperidino-1,3-oxathiolium perchlorate, which underwent nucleophilic reaction with NH3 and the 5-ethoxycarbonylmethyl-4-phenyl-2-piperidinothiazole hydrolyzed to give I (R = piperidino, R1 = H, R2 = Ph). I were also synthesized by the classical Hantzsch method. I were evaluated as antiinflammatory agents on carrageenin induced abscess in rats.
Chemical & Pharmaceutical Bulletin published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, COA of Formula: C5H10N2OS.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics