He, Haifeng published the artcileSynthesis, antitumor activity and mechanism of action of novel 1,3-thiazole derivatives containing hydrazide-hydrazone and carboxamide moiety, SDS of cas: 2447-79-2, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(14), 3263-3270, database is CAplus and MEDLINE.
A series of novel 2,4,5-trisubstituted 1,3-thiazole derivatives containing hydrazide-hydrazine and carboxamide moieties including 46 compounds T were synthesized, and evaluated for their antitumor activity in vitro against a panel of five human cancer cell lines. Eighteen title compounds T displayed higher inhibitory activity than that of 5-Fu against MCF-7, HepG2, BGC-823, Hela, and A549 cell lines. Especially, I, II, and III exhibit best cytotoxic activities with IC50 values of 2.21 μg/mL, 1.67 μg/mL, and 1.11 μg/mL, against MCF-7, BCG-823, and HepG2 cell lines, resp. These results suggested that the combination of 1,3-thiazole, hydrazide-hydrazone, and carboxamide moieties was favorable to cytotoxicity activity. Furthermore, the flow cytometry anal. revealed that compounds I and III could induce apoptosis in HepG2 cells, and it was confirmed III led the induction of cell apoptosis by S cell-cycle arrest.
Bioorganic & Medicinal Chemistry Letters published new progress about 2447-79-2. 2447-79-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Amide, name is 2,4-Dichlorobenzamide, and the molecular formula is C7H5Cl2NO, SDS of cas: 2447-79-2.
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https://en.wikipedia.org/wiki/Amide,
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