Dermenci, Alpay published the artcileRh-catalyzed decarbonylation of conjugated ynones via carbon-alkyne bond activation: reaction scope and mechanistic exploration via DFT calculations, Name: N-Methoxy-N-methylisonicotinamide, the publication is Chemical Science (2015), 6(5), 3201-3210, database is CAplus and MEDLINE.
Detailed development of a catalytic decarbonylation of conjugated monoynones to synthesize disubstituted alkynes was described. The reaction scope and limitation has been thoroughly investigated, and a broad range of functional groups including heterocycles were compatible under the catalytic conditions. Mechanistic exploration via DFT calculations has also been executed. Through the computational study, a proposed catalytic mechanism has been carefully evaluated. These efforts are expected to serve as an important exploratory study for developing catalytic alkyne-transfer reactions via carbon-alkyne bond activation.
Chemical Science published new progress about 100377-32-0. 100377-32-0 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N-Methoxy-N-methylisonicotinamide, and the molecular formula is C8H10N2O2, Name: N-Methoxy-N-methylisonicotinamide.
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https://en.wikipedia.org/wiki/Amide,
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