Alaeddin, Nersi published the artcileValidation of self-reported medication use applying untargeted mass spectrometry-based metabolomics techniques in the Rhineland study, Product Details of C24H29N5O3, the publication is British Journal of Clinical Pharmacology (2022), 88(5), 2380-2395, database is CAplus and MEDLINE.
To assess the validity of self-reported continuous medication use with drug metabolites measured in plasma by using untargeted mass spectrometric techniques. In a population-based cohort in Bonn, Germany, we compared interview-based, self-reported medication intake with drug-specific metabolites measured in plasma (based on participants who completed their study visits between March 2016 and Feb. 2020). Analyses were done stratified by sex and age (<65 years vs ≥65 years). Cohen’s kappa (κ) statistics with 95% confidence intervals (CI) were calculated A total of 13 drugs used to treat hypertension, gout, diabetes, epilepsy and depression were analyzed in a sample of 4386 individuals (mean age 55 years, 56.1% women). Eleven drugs showed almost perfect agreement (κ > 0.8), whereas sitagliptin and hydrochlorothiazide showed substantial (κ = 0.8, 95% CI 0.71-0.90) and moderate agreement (κ = 0.61, 95% CI 0.56-0.66), resp. Frequency of use allowed sex- and age-stratified analyses for eight and nine drugs, resp. For five drugs, concordance tended to be higher for women than for men. For most drugs, concordance was higher among individuals aged ≥65 years than among individuals aged <65 years, but these age-related differences were not statistically significant. High concordance rates between self-reported drug use and metabolites measured in plasma suggest that self-reported drug use is reliable and accurate for assessing drug use.
British Journal of Clinical Pharmacology published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, Product Details of C24H29N5O3.
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