Ogami, Keisuke published the artcileA pot-economical liquid-phase peptide nucleic acid synthesis enabled by a soluble tag-assisted method, Computed Properties of 186046-83-3, the publication is Chemistry Letters (2018), 47(2), 138-140, database is CAplus.
In a peptide nucleic acid (PNA), the base sequences are arranged onto a backbone of repeating units of N-(2-aminoethyl)glycine instead of on phosphodiester-linked riboses. PNA is a promising platform for the design of novel chem. probes because PNAs can form complementary base pairs with DNA and RNA that exhibit high enzymic stability. Described herein is a pot-economical liquid-phase PNA synthesis achieved using a soluble tag-assisted method. Intramol. trapping of the activated PNA monomer occurs much faster than the undesired intermol. “double hit”. Consequently, excess PNA monomers do not have to be rinsed away after each coupling, enabling one-pot coupling and deprotection without the need for precipitation
Chemistry Letters published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Computed Properties of 186046-83-3.
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