Nagl, Michael published the artcileThe BF3.OEt2-assisted conversion of nitriles into thioamides with Lawesson’s reagent, SDS of cas: 64559-06-4, the publication is Synthesis (2008), 4012-4018, database is CAplus.
A method for the thiolysis of nitriles by applying Lawesson’s reagent and facilitated by the addition of BF3.OEt2 is reported. The method opens an easy access to primary thioamides. Aromatic, benzylic, and aliphatic nitriles were converted into the corresponding thioamides in high to quant. yields (even in unfavorable cases, e.g., ortho-substituted benzonitriles). The reaction was performed in MeO(CH2)2OMe/THF or PhMe/OEt2 solvent mixtures at 20-50°, and exhibited considerable selectivity in the case of multifunctional nitrile substrates, such as cyanomethyl N-acetylphenylalaninate, BzCH2CN, 4-NCC6H4CONH2, 4-AcC6H4CN, or 3-pentenenitrile.
Synthesis published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C8H9NOS, SDS of cas: 64559-06-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics