Mohammad Shafiee, M. R. published the artcileHighly Efficient and Green Synthesis of Indole and Benzofuran Derivatives via Electrochemical Methods under ECECCC Mechanism, Name: 2-Cyano-N-ethylacetamide, the publication is Journal of the Electrochemical Society (2017), 164(13), G105-G111, database is CAplus.
Electrochem. synthesis of novel benzofuran and indole derivatives was carried out by the electrochem. oxidation of hydroquinone, 4-aminophenol and p-phenylenediamine in the presence of cyanoacetamide and 2-cyano-n-ethylacetamide as nucleophiles in a phosphate buffer solution (PBS) mixed with ethanol as a green solvent using cyclic voltammetry, controlled-potential coulometry, and UV-spectroscopy methods. The oxidized form of hydroquinone, 4-aminophenol, and p-phenylenediamine participate in the 1,4-Michael addition reactions with cyanoacetamides via the ECECCC mechanism for the electrochem. synthesis of new benzofuran and indole derivatives with good yield and high purity under controlled potential conditions. In this method, a carbon rod was used as the anode and the use of toxic and/or hazardous reagents was avoided. The obtained products were characterized after purification by the FTIR, 1HNMR, 13C NMR and elemental anal. The present work led to the development of a facile and environmentally friendly reagent-less electrochem. method with high atom economy and safer waste under green conditions.
Journal of the Electrochemical Society published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Name: 2-Cyano-N-ethylacetamide.
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https://en.wikipedia.org/wiki/Amide,
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