McCarthy, Anna R. published the artcileSynthesis and biological characterisation of sirtuin inhibitors based on the tenovins, Application of N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide, the publication is Bioorganic & Medicinal Chemistry (2012), 20(5), 1779-1793, database is CAplus and MEDLINE.
The tenovins are small mol. inhibitors of the NAD+-dependent family of protein deacetylases known as the sirtuins. There remains considerable interest in inhibitors of this enzyme family due to possible applications in both cancer and neurodegenerative disease therapy. Through the synthesis of novel tenovin analogs, further insights into the structural requirements for activity against the sirtuins in vitro are provided. In addition, the activity of one of the analogs in cells led to an improved understanding of the function of SirT1 in cells.
Bioorganic & Medicinal Chemistry published new progress about 380315-80-0. 380315-80-0 belongs to amides-buliding-blocks, auxiliary class Apoptosis,p53, name is N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide, and the molecular formula is C20H23N3O2S, Application of N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide.
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