Khandaka, Himanshu published the artcileAerobic Cu and amine free Sonogashira and Stille couplings of aryl bromides/chlorides with a magnetically recoverable Fe3O4@SiO2 immobilized Pd(II)-thioether containing NHC, Recommanded Product: 2-Chloroacetamide, the publication is Tetrahedron Letters (2021), 152844, database is CAplus.
Two value added C-C cross coupling reactions; Sonogashira and Stille couplings were achieved at milder conditions in the catalytic presence of a magnetically recoverable heterogeneous catalyst Fe3O4@SiO2 immobilized Pd(II)-thioether containing NHC. The catalyst was earlier reported for Suzuki-Miyaura reaction and as an extension of its catalytic efficiency, the Stille and Sonogashira cross coupling reactions under aerobic condition had been explored in present report. The Sonogashira coupling of aryl bromides and terminal alkynes produced an excellent yield (∼96% at 0.25 mol% Pd) of the desired coupling product under copper and amines free conditions. Moreover, an excellent Stille coupling of readily available and more latent aryl chlorides and trialkylstannane was obtained (yields up to 95% at 0.25 mol% Pd) in absence of toxic fluorides additives. The broad substrate scope of the catalyst for both the coupling reactions and the magnetically recoverable feature of catalyst made this reaction highly desirable for industrial applications of present heterogeneous catalysis.
Tetrahedron Letters published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Recommanded Product: 2-Chloroacetamide.
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