Jack, Thomas published the artcileSynthesis and characterization of photoaffinity probes that target the 5-HT3 receptor, Application of N,N-Diethyl-2,2,2-trifluoroacetamide, the publication is Chimia (2014), 68(4), 239-242, database is CAplus and MEDLINE.
The 5-HT3 receptor is one of several ion channels responsible for the transmission of nerve impulses in the peripheral and central nervous systems. Until now, it was difficult to characterize transmembrane receptors with classical structural biol. approaches like x-ray crystallog. The use of photoaffinity probes is an alternative approach to identify regions in the protein where small mols. bind. To this end, the authors present two photoaffinity probes based on granisetron, a well known antagonist of the 5-HT3 receptor. These new probes show nanomolar binding affinity for the orthosteric binding site. In addition, the authors investigated their reactivity using irradiation experiments
Chimia published new progress about 360-92-9. 360-92-9 belongs to amides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain,Amide, name is N,N-Diethyl-2,2,2-trifluoroacetamide, and the molecular formula is C6H10F3NO, Application of N,N-Diethyl-2,2,2-trifluoroacetamide.
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https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics