Gomez-Carpintero, Jorge published the artcileMechanochemical Synthesis of Primary Amides, Recommanded Product: Isonicotinamide, the publication is Journal of Organic Chemistry (2021), 86(20), 14232-14237, database is CAplus and MEDLINE.
Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters RCOOEt (R = 3-fluorophenyl, 1,3-diethoxy-1,3-dioxopropan-2-yl, thiophen-2-yl, etc.) and 2-chromanone with ethanol and calcium nitride afforded the corresponding primary amides RC(O)NH2in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodol. was applied to α-amino esters (S)-H2NCH(CH2R1)C(O)OEt [R1 = Ph, (methylsulfanyl)methyl] and N-Boc dipeptide esters (S)-(CH3)3COC(O)NHCH(CH2R2)C(O)NHCH2C(O)OEt (R2 = H, Ph, 1H-indol-3-yl) and also to the synthesis of rufinamide, an antiepileptic drug.
Journal of Organic Chemistry published new progress about 1453-82-3. 1453-82-3 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is Isonicotinamide, and the molecular formula is C6H6N2O, Recommanded Product: Isonicotinamide.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics