Forkel, Susann published the artcileThe benefit of late readings in patch testing depends both on allergen and patient characteristics, HPLC of Formula: 79-07-2, the publication is Allergy (Oxford, United Kingdom) (2022), 77(5), 1477-1485, database is CAplus and MEDLINE.
Patch test (PT) readings are recommended after 48 h and 72 h (D3). An addnl. day 7 (D7) reading has been suggested by some, although data on efficient patient selection are scarce. We investigated pos. D7 reactions regarding (i) allergens in the baseline series and addnl. PT series of the German Contact Dermatitis Research Group (DKG) and (ii) characteristics of the patients tested. Retrospective, multicentre anal. of 190 allergens derived from 17 DKG test series in 4687 patients with an addnl. D7 reading. Patients were patch tested with the baseline series and addnl. series, if required. Occurrence of novel D7 reactions as well as increasing skin reactions from D3 to D7 was analyzed sep. Depending on the allergen tested, waiving D7 readings would have missed 4.4-26.8% of pos. PT results. Patch test series with the highest number of novel D7 reactions were baseline series, metal series, and leather/shoe series. New pos. reactions on D7 were associated with age over 50 years and with a neg. irritant control containing sodium lauryl sulfate. Of note, application of the PT allergens for 48 h instead of 24 h was pos. associated with late PT reactions. Within the most frequently tested allergens, without late readings, on average 11.7% of sensitizations would have been missed. Novel late reacting allergens were identified. This study comprehensively dissects patient-, allergen- and test-dependent parameters in support for D7 readings. We propose to always consider late readings individually based on effort-benefit considerations.
Allergy (Oxford, United Kingdom) published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, HPLC of Formula: 79-07-2.
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