Devani, M. B. published the artcileSynthesis and pharmacological properties of some 4-amino-5-substituted thiazole-2(3H)-thiones and thiazolo(4,5-d)pyrimidin-7(6H)-one-2(3H)-thiones, Recommanded Product: 2-Cyano-N-ethylacetamide, the publication is Arzneimittel-Forschung (1977), 27(9), 1652-5, database is CAplus and MEDLINE.
Twenty-six aminothiazolethiones I (R = Et, benzyl, allyl, Ph, tolyl, etc.; R1 = NH2, NHMe, piperidino, morpholino, PhNHNH) were prepared in 40-90% yield by reaction of RNCS with NCCH2CONHR1. Eleven thiazolopyrimidinones II (R = benzyl, tolyl, Ph, Me, Et, R2 = H, Me, Et, Ph, anilino) were prepared in 55-70% yield by reaction of the appropriate I with HC(OEt)2 in Ac2O. I and II were screened for antimicrobial and pharmacol. activities. Maximum antiinflammatory activity was found in I (R = o-tolyl, R1 = morpholino); at 200 mg/kg its activity was almost equal to phenylbutazone at 100 mg/kg. I (R = allyl, R1 = PhNHNH) was the most active antimicrobial of the series. I (R = benzyl, R1 = NH2) was the most potent analgesic.
Arzneimittel-Forschung published new progress about 15029-36-4. 15029-36-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Aliphatic hydrocarbon chain,Amide, name is 2-Cyano-N-ethylacetamide, and the molecular formula is C5H8N2O, Recommanded Product: 2-Cyano-N-ethylacetamide.
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