Bahgat, Eman A. published the artcileDevelopment and validation of eco-friendly micellar organic solvent-free HPLC method for the simultaneous determination of some antihypertensive combinations, Computed Properties of 137862-53-4, the publication is Microchemical Journal (2022), 107740, database is CAplus.
To minimize the environmental impacts of using organic solvent without affecting the chromatog. performance, alternatives had to be utilized to decrease such pollution. Combination of sodium dodecyl sulfate (SDS) with polyoxyethylene-23-lauryl ether (Brij-35) could be incorporated as a green alternative for using organic solvents as mobile phases in HPLC separation systems. In this research, a micellar organic solvent-free HPLC method have be established for determination of five antihypertensive drugs, namely, captopril (CPT), hydrochlorothiazide (HCT), indapamide (IND), valsartan (VAL) and carvedilol (CAR). The most favorable conditions were validated using mobile phase consists of 0.1 mol/L SDS, 0.03 mol/L Brij-35, adjusted at pH 2.8 using ortho-phosphoric acid on symmetry C18 column and detection at 210 nm. The flow rate was sudden increased from 1.2 to 1.5 mL/min after two minutes and the total separation run time was nine minutes. The method was successfully applied to determine four different combinations of the analytes in bulk and their pharmaceutical dosage forms. Method validation was done according to International Conference of Harmonization guidelines. At linearity range of 5-100μg/mL for CPT, HCT and CAR, 8 – 160μg/mL for VAL, and 2 – 40μg/mL for IND, high accuracy results were found. Moreover, the coefficient of the variation of the points of the calibration curve being below 2% indicating precise method. The LLOQ was (4.88μg/mL) for CPT, (4.89μg/mL) for HCT and CAR, (7.91μg/mL) for VAL, and (1.81μg/mL) for IND. The method’s greenness was determined with the help of an eco-scale scoring method, Green Anal. Procedure Index, and Anal. Greenness Calculator and the proposed method was found to be an excellent green methodol.
Microchemical Journal published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, Computed Properties of 137862-53-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics