Month: November 2022

On February 15, 2022, Muranaka, Ryo; Liu, Yue; Okada, Itsuumi; Okazoe, Takashi; Tsuda, Akihiko published an article.Quality Control of 1,3-Diphenylurea The title of the article was Photo-on-Demand Phosgenation Reactions with Chloroform for Selective Syntheses of N-Substituted Ureas and Isocyanates. And the article contained the following:

Two new reaction processes involving the in situ oxidative photochem. conversion of CHCl3 to COCl2 allowed selective syntheses of N-substituted ureas and isocyanates from amines. (I) A CHCl3 solution containing an amine and an organic base under O2 bubbling provided the urea derivative under exposure to UV light generated from a low-pressure mercury lamp at 20-40°C. (II) A two-step reaction involving the oxidative photodecomposition of CHCl3 at lower temperatures and subsequent sequential injections of an amine and organic base into the sample solution provided the isocyanate in high yield. The reaction processes of (I) and (II) capitalize on the solution conditions of [COCl2] < [amine] and [COCl2] > [amine], resp., to result in 1:2 and 1:1 reactions. In general, isocyanates, especially aromatic and haloalkyl ones, readily undergo hydrolysis in the presence of an organic base. However, with the advantage of synthesizing the isocyanates in CHCl3 solvent, direct addition of monoalcs. and diols to the as-prepared sample solution containing the diisocyanate allowed the one-pot syntheses of biscarbamates and polyurethanes, resp. The reactions developed in this study are simple, safe, and inexpensive methods of synthesizing N-substituted ureas and isocyanates, and derivatives of isocyanates such as carbamates and polyurethanes. The present new methods can replace current synthetic methods using COCl2 in both academia and industry. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Quality Control of 1,3-Diphenylurea

The Article related to substituted urea isocyanate preparation, chloroform amine phosgenation oxidative photochem, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Quality Control of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Matsuura, Akihisa; Ano, Yusuke; Chatani, Naoto published an article in 2022, the title of the article was Nucleophilic aromatic substitution of non-activated aryl fluorides with aliphatic amides.Related Products of 685-91-6 And the article contains the following content:

Nucleophilic aromatic substitution (SNAr) reactions of non-activated aryl fluorides RF [R = (4-biphenyl), [4-(pyridin-2-yl)phenyl], naphthalen-1-yl, pyridin-3-yl, etc.] with amide enolates e.g., 1-methylpyrrolidin-2-one are reported. The reaction proceeds under relatively mild reaction conditions. Lactams also participate in the reaction to give 2-arylated lactams e.g., I. DFT calculations suggest that the reaction proceeds through a concerted SNAr pathway. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Related Products of 685-91-6

The Article related to amide preparation, aliphatic amide aryl fluoride nucleophilic aromatic substitution reaction, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Related Products of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 20, 2018, Zhou, Xibing; Zhang, Guoying; Gao, Bao; Huang, Hanmin published an article.Reference of N,N-Diethylacetamide The title of the article was Palladium-Catalyzed Hydrocarbonylative C-N Coupling of Alkenes with Amides. And the article contained the following:

Terminal alkenes such as styrene and norbornene underwent regioselective hydrocarbonylation and acyl metathesis reactions with amides such as DMF using NH4Cl or N-methylpyrrolidine hydrochloride as additive under 10 atm. CO pressure at 120° in the presence of either Pd(Pt-Bu3)2 or Pd(MeCN)2Cl2 and Xantphos to yield amides such as PhCHMeCONMe2 or PhCH2CH2CONMe2, resp. N-alkenylamides underwent intramol. hydrocarbonylation and acyl metathesis reactions to yield lactams. Use of NMP·DCl as additive yielded partially deuterated amides. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Reference of N,N-Diethylacetamide

The Article related to amide regioselective preparation, palladium catalyst regioselective hydrocarbonylation metathesis alkene amide, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Reference of N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Iacobucci, Claudio; Jouini, Nedra; Massi, Lionel; Olivero, Sandra; De Angelis, Francesco; Dunach, Elisabet; Gal, Jean-Francois published an article in 2017, the title of the article was Quantitative Ligand Affinity Scales for Metal Triflate Salts: Application to Isomer Differentiation.Synthetic Route of 685-91-6 And the article contains the following content:

Owing to the importance of metal triflates in catalysis, the affinity of the cationic center for a selection of organic ligands was explored for InIII and ZnII triflates. The organic Lewis bases include a variety of carbonyls (amides, unsaturated ketones, a lactone) and cyclic 1,2-diols. The relative affinity of the ligands for the cationic center in triflates was quant. determined on the basis of relative ion concentrations determined by electrospray-ionization mass spectrometry. The affinity scales were discussed with reference to gas-phase proton basicity and Lewis basicity scales. Structural isomers and stereoisomers display significant affinity differences in several cases. In the case of isomer mixtures, a model describing the relative peak intensities in the mass spectra was developed. On this basis, an isomer titration method was set up. Remarkably, this MS-based method overcame the blindness of mass spectrometry to isomers without the need for isotope labeling or MS/MS experiments This model may prove to have applications in anal. chem. and catalysis. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Synthetic Route of 685-91-6

The Article related to metal triflate salt isomer differentiation ligand affinity, lewis acids, affinity, isomer recognition, mass spectrometry, metal triflates, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Synthetic Route of 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2021, Medo, Juraj; Makova, Jana; Medova, Janka; Lipkova, Nikola; Cinkocki, Renata; Omelka, Radoslav; Javorekova, Sona published an article.Name: 2-Chloroacetamide The title of the article was Changes in soil microbial community and activity caused by application of dimethachlor and linuron. And the article contained the following:

Soil microorganisms and their activities are essential for maintaining soil health and fertility. Microorganisms can be neg. affected by application of herbicides. Although effects of herbicides on microorganisms are widely studied, there is a lack of information for chloroacetamide herbicide dimethachlor. Thus, dimethachlor and well known linuron were applied to silty-loam luvisol and their effects on microorganisms were evaluated during112 days long laboratory assay. Dimethachlor and linuron were applied in doses 1.0 kg ha-1 and 0.8 kg ha-1 corresponding to 3.33 mg kg-1 and 2.66 mg kg-1 resp. Also 100-fold doses were used for magnification of impacts. Linuron in 100-fold dose caused minor increase of respiration, temporal increase of soil microbial biomass, decrease of soil dehydrogenase activity, and altered microbial community. Dimethachlor in 100-fold dose significantly increased respiration; microbial biomass and decreased soil enzymic activities. Microbial composition changed significantly, Proteobacteria abundance, particularly Pseudomonas and Achromobacter genera increased from 7 to 28th day. In-silico prediction of microbial gene expression by PICRUSt2 software revealed increased expression of genes related to xenobiotic degradation pathways. Evaluated characteristics of microbial community and activity were not affected by herbicides in recommended doses and the responsible use of both herbicides will not harm soil microbial community. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Name: 2-Chloroacetamide

The Article related to dimethachlor linuron soil microbial community activity, Fertilizers, Soils, and Plant Nutrition: Fertilizer-Soil Relations, Including Amendments and other aspects.Name: 2-Chloroacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Haowen; Feng, Jiajie; Zhou, Wei; Chen, Chen; Deng, Zhuoji; Zhou, Fengtao; Ouyang, Yifan; Zhang, Xinhao; Cai, Qian published an article in 2021, the title of the article was Copper(I)-catalyzed asymmetric intramolecular C-arylation with ureas as the additives: highly enantioselective formation of spirooxindoles.Application of 102-07-8 And the article contains the following content:

An enantioselective synthesis of spirooxindoles I [Y = CH2, O, NMe; R = Me, allyl, Bn, etc.; R1 = H, 5-F, 6-Me, etc.] via copper-catalyzed asym. intramol. C-arylation reaction with ureas as the co-catalysts was developed. By formation of hydrogen bonds with 1,3-dicarbonyl structures, ureas could activate the substrates, stabilize the carbanion intermediates and the products, and fix the syn-configurations of 1,3-dicarbonyl structures. They help enhance the reactivity, prevent side reactions and improve the enantioselectivities. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to spirooxindole enantioselective preparation, cyclic beta ketoamide preparation copper catalyst ullmann hurtley arylation, Heterocyclic Compounds (One Hetero Atom): Spiro Compounds With One Hetero Atom In Each Ring and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 31, 2017, Ozturk Urut, Gulsiye; Alp, Serap; Topkaya, Derya published an article.Recommanded Product: 2-(4-Methylbenzamido)acetic acid The title of the article was Synthesis and characterization of new green and orange region emitting anthracene based oxazol-5-one dyes. And the article contained the following:

New anthracene oxazol-5-one dyes featuring an extended π-conjugated electron system have been successfully prepared by Erlenmeyer synthesis, structurally characterized and their spectroscopic properties were investigated by UV-vis absorption spectroscopy and fluorescence spectroscopy. The oxazol-5-ones were attached to the 9-position of the anthracene to obtain the desired structures. The dyes are having extended conjugation throughout their structure with oxazol-5-one ring as the chromophore. The spectral properties of the oxazol-5-one ring were monitored with respect to the substituents at the Ph ring. All of the dyes synthesized show good solubility in common organic solvents. Also in order to establish whether there was any solvent affects the absorption and emission spectra of the compounds were measured in the solvents of acetonitrile, THF and chloroform which have different polarity. Moreover, their absorption and emission properties were investigated in plasticized PVC film matrix. In comparison to the solution phase, the dyes displayed enhanced fluorescence emission quantum yield values when embedded in poly(vinyl chloride) polymer film. The anthracene based oxazol-5-ones were found to emit in the green portion of the spectrum for 2a and 2b, and in the orange portion of the spectrum for 2c. By attachment of nitro substituent at the para position of the Ph ring bound to oxazol-5-one core, the fluorescence maxima could be effectively modulated from the green region of the spectra to the orange region. 4-(9-anthralydene)-2-(4-nitrophenyl)oxazol-5-one (2c) exhibits large Stokes shift up to 146 nm presumably due to intramol. charge transfer. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Recommanded Product: 2-(4-Methylbenzamido)acetic acid

The Article related to anthracene based oxazolone dye solubility fluorescence, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Heterocyclics and other aspects.Recommanded Product: 2-(4-Methylbenzamido)acetic acid

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 25, 2014, Alexander, Matthew David; McDonald, Joseph John; Ni, Yike; Niu, Deqiang; Petter, Russell C.; Qiao, Lixin; Singh, Juswinder; Wang, Tao; Zhu, Zhendong published a patent.Recommanded Product: N-(3-Aminophenyl)acrylamide The title of the patent was Preparation of heteroaryl compounds as Mk2 kinase inhibitors. And the patent contained the following:

The title compound with general formula I [wherein Ring A = optionally substituted group selected from a 3-8 membered carbocyclic ring, a 4-7 membered heterocylic ring, a 5-6 membered monocyclic heteroaryl ring, a 7-10 membered bicyclic aryl ring, etc.; Y = CR’ or N, where each R’ is independently hydrogen, halo, an optionally substituted Ph, a 3-8 membered carbocyclic ring, etc.; R1 = a warhead group; q = 0-6; R2 = independently halogen, -OH, -SH, -CN, etc.; R3 and R4 = independently optionally substituted Ph, a 3-8 membered carbocyclic ring, a 4-7 membered heterocylic ring, etc.; R5 = independently hydrogen or an optionally substituted C1-6 aliphatic group; T = a covalent bond, -O-, -S-, -C(O)-, etc.] or pharmaceutically acceptable salts thereof were prepared as Mk2 kinase inhibitors. For example, compound II was prepared in a multi-step synthesis. The title compounds can be used for the treatment of autoimmune disorder, chronic or acute inflammatory disorder, auto-inflammatory disorder, neoplasia, cardiovascular, or cerebrovascular disease. (pharmaceutical assay data given). The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Recommanded Product: N-(3-Aminophenyl)acrylamide

The Article related to preparation heteroaryl compound mk2 kinase inhibitor human, treatment neoplasia autoimmune chronic acute inflammatory cardiovascular cerebrovascular disease, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Recommanded Product: N-(3-Aminophenyl)acrylamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 1, 2021, Legacy, Christopher J.; Hope, Taylor O.; Gagne, Yohann; Greenaway, Frederick T.; Frenette, Mathieu; Emmert, Marion H. published an article.SDS of cas: 685-91-6 The title of the article was Mechanistic Insights into Fe Catalyzed α-C-H Oxidations of Tertiary Amines. And the article contained the following:

We report detailed mechanistic investigations of an iron-based catalyst system, which allows the α-C-H oxidation of a wide variety of amines. In contrast to other catalysts that effect α-C-H oxidations of tertiary amines, the system under investigation exclusively employs peroxy esters as oxidants. More common oxidants (e. g. tBuOOH) previously reported to affect amine oxidations via free radical pathways do not provide amine α-C-H oxidation products in combination with the described catalyst system. The investigations described herein employ initial rate kinetics, kinetic profiling, DFT calculations as well as Eyring, kinetic isotope effect, Hammett, ligand coordination, and EPR studies to shed light on the Fe catalyst system. The obtained data suggest that the catalytic mechanism proceeds through C-H abstraction at a coordinated substrate mol. This rate-determining step occurs either through an Fe(IV) oxo pathway or a 2-electron pathway at an Fe(II) intermediate with bound oxidant. DFT calculations indicate that the Fe(IV) oxo mechanism will be the preferred route of these two possibilities. We further show via kinetic profiling and EPR studies that catalyst activation follows a radical pathway, which is initiated by hydrolysis of PhCO3tBu to tBuOOH. Overall, the obtained mechanistic data support a non-classical, Fe catalyzed pathway that requires substrate binding, inducing selectivity for α-C-H functionalization. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6

The Article related to tripropylamine iron oxidation mechanism kinetics hammett constant, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.SDS of cas: 685-91-6

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cardenal, Ashley D.; Jeong Park, Hye; Chalker, Cody J.; Ortiz, Kacey G.; Powers, David C. published an article in 2017, the title of the article was cis-Decalin oxidation as a stereochemical probe of in-MOF versus on-MOF catalysis.Recommanded Product: N,N-Diethylacetamide And the article contains the following content:

Development of catalyst-controlled C-H hydroxylation could provide direct access to valuable synthetic targets, such as primary metabolites. Here, we report a new family of porous materials, comprised of 2-dimensional metalloporphyrin layers and flexible aliphatic linkers, and demonstrate C-H hydroxylation activity. We demonstrate that the stereochem. of cis-decalin oxidation provides a useful tool for differentiating catalysis in from catalysis on porous materials, which is critical to leveraging the potential of porous materials for catalyst-controlled oxidation chem. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Recommanded Product: N,N-Diethylacetamide

The Article related to metal organic framework porous catalyst hydroxylation stereoselectivity, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Recommanded Product: N,N-Diethylacetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics