Wang, Daoxin published the artcileAlternating Current Electrolysis Enabled Formal C-O/O-H Cross-Metathesis of 4-Alkoxy Anilines with Alcohols, Recommanded Product: 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, the publication is Angewandte Chemie, International Edition (2022), 61(18), e202201543, database is CAplus and MEDLINE.
A new protocol to achieve the formal C-O/O-H cross-metathesis via a.c. electrolysis was reported. Featuring mild reaction conditions, the protocol allowed readily available 4-alkoxy anilines and alcs. to be converted into a wide range of valuable complex 4-alkoxy anilines I [R = n-Bu, (CH2)2OH, (CH2)4OH, etc.; R1 = t-BuC(O), Ts, 4-MeOC6H4C(O), etc.; R2 = H, 2-Me, 3-Cl, etc.] in highly regioselective and chemoselective manner. Moreover, the present strategy could be used in the late-stage modification of pharmaceuticals as well as biol. active compounds, which demonstrated the potential application.
Angewandte Chemie, International Edition published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C8H5F3O3, Recommanded Product: 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide.
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