Sugiyama, Toru published the artcileβ-PNA: Peptide nucleic acid (PNA) with a chiral center at the β-position of the PNA backbone, Category: amides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(24), 7317-7320, database is CAplus and MEDLINE.
Peptide nucleic acid (PNA) monomers with a Me group at the β-position have been synthesized. The modified monomers were incorporated into PNA oligomers using Fmoc chem. for solid-phase synthesis. Thermal denaturation and CD studies have shown that PNA containing the S-form monomers was well suited to form a hybrid duplex with DNA, whose stability was comparable to that of unmodified PNA-DNA duplex, whereas PNA containing the R-form monomers was not.
Bioorganic & Medicinal Chemistry Letters published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C27H29N5O5, Category: amides-buliding-blocks.
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https://en.wikipedia.org/wiki/Amide,
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