Scott, Fraser J. published the artcileAn evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics, Quality Control of 64559-06-4, the publication is European Journal of Medicinal Chemistry (2016), 116-125, database is CAplus and MEDLINE.
A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimization towards novel treatments for Human and Animal African Trypanosomiases. Moreover, SAR indicates that the head group linking moiety is a significant modulator of biol. activity.
European Journal of Medicinal Chemistry published new progress about 64559-06-4. 64559-06-4 belongs to amides-buliding-blocks, auxiliary class Amine,Benzene,Amide,Ether, name is 3-Methoxybenzothioamide, and the molecular formula is C14H21BO2, Quality Control of 64559-06-4.
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