Mokariya, Jaydeep A. published the artcileSimultaneous ultrasound- and microwave-assisted one-pot ‘click’ synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation, Name: 2-Chloroacetamide, the publication is Molecular Diversity (2022), 26(2), 963-979, database is CAplus and MEDLINE.
An environment friendly, high yielding, promising one-pot protocol for the click reaction of N-propargyl-3-formylindoles, chloroacetic acid/ester and sodium azide, leading to the formation of 3-formyl-indole clubbed 1,4-disubstituted-1,2,3-triazole derivatives I [R = OH, OEt, Ph, etc.; R1 = H, Me] aided by CuI catalyst accomplished under acceleration of simultaneous ultrasound and microwave irradiation in a very short reaction time was described. Further, acid derivatives I [R = OH; R1 = H, Me] were subjected to acid-amine coupling reaction with secondary amines in the presence of HATU to afford triazoles II [R2 = 4-methylpiperidin-1-yl, 2-morpholino, 1,2,3-triazol-1-yl, etc.]. The perspective of this protocol was to get rid of the hectic preparation and handling of organic azide which are generated in situ. Consequently, this protocol blossomed the click process by making it environment benign, user-friendly, safe and clean technique. All the synthesized compounds were preliminarily screened for their in vitro antimicrobial activity against a panel of pathogenic strains. The majority of compounds possessed noticeably inhibitory action against E. Coli, S. Typhi, P. Aeruginosa, C. tetani, S. aureus and B. subtillis. Among all compounds, I [R1 = H, R2 = 4-methylpiperidin-1-yl; R1 = Me, R2 = 4-methylpiperazin-1-yl] exhibited excellent inhibitory action against E.Coli and P. Aeruginosa strain, resp., as compared to standard drug. One compound I [R = Me, R1 = OEt] showed remarkable potency against fungal strain. Mol. docking study was carried out to understand binding of compound with protein. In silico ADME prediction was carried out to check physicochem. properties of synthesized compound
Molecular Diversity published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Name: 2-Chloroacetamide.
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https://en.wikipedia.org/wiki/Amide,
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