Meguellati, Kamel published the artcileDNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic Reaction for Sensing G-Quadruplex Formation, Application In Synthesis of 186046-83-3, the publication is Angewandte Chemie, International Edition (2010), 49(15), 2738-2742, S2738/1-S2738/17, database is CAplus and MEDLINE.
The fluorogenic synthesis of a sym. or unsym. trimethine cyanine dye by an aldolization-elimination reaction between two nonfluorescent precursors was applied for sensing G-quadruplex formation in vitro. Two peptide nucleic acids PNAs were designed that can each hybridize in a sequence-specific manner with five nucleobases upstream and five nucleobases downstream of the parallel-stranded ckit21T quadruplex chosen as a model system. They were functionalized at their C-terminal or N-terminal end with either an N-alkyl-2-methyleneindoline (Ind1-3) or an N-alkyl-2-(3,3-dimethylindolin-2-ylidene)acetaldehyde (Aid). Two ε-N,N-dimethyllysine residues per PNA strand were also added to ensure solubility of both PNAs in water at near-physiol. pH.
Angewandte Chemie, International Edition published new progress about 186046-83-3. 186046-83-3 belongs to amides-buliding-blocks, auxiliary class Purine,Carboxylic acid,Amine,Benzene,Amide,Others,PNA,, name is 2-(N-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)ethyl)-2-(2-(((benzhydryloxy)carbonyl)amino)-6-oxo-5H-purin-9(6H)-yl)acetamido)acetic acid, and the molecular formula is C40H35N7O8, Application In Synthesis of 186046-83-3.
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