Liu, Yang published the artcilePyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase, Application In Synthesis of 849833-86-9, the publication is European Journal of Medicinal Chemistry (2016), 322-333, database is CAplus and MEDLINE.
Over activation of c-Met tyrosine kinase is known to promote tumorigenesis and metastasis, as well as therapeutic resistance. Herein the authors describe the design, synthesis and biol. activities of novel, ATP-competitive, c-Met tyrosine kinase inhibitors that are members of the 6-aryl-2-(3-(heteroarylamino)benzyl)pyridazinone family. A structure-activity relationship (SAR) study of these substances led to identification of a pyridazinone derivative as a highly selective and potent c-Met tyrosine inhibitor, which displays favorable pharmacokinetic properties in mice and significant antitumor activity against a c-Met driven EBC-1 tumor xenograft. The synthesis of the target compounds was achieved using [(3-iodophenyl)methyl]-3-pyridazinone derivatives as key intermediates.
European Journal of Medicinal Chemistry published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Application In Synthesis of 849833-86-9.
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