Lain, Sonia published the artcileDiscovery, in vivo activity, and mechanism of action of a small-molecule p53 activator, HPLC of Formula: 380315-80-0, the publication is Cancer Cell (2008), 13(5), 454-463, database is CAplus and MEDLINE.
We have carried out a cell-based screen aimed at discovering small mols. that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6. Via a yeast genetic screen, biochem. assays, and target validation studies in mammalian cells, we show that tenovins act through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family. Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. This underscores the utility of these compounds as biol. tools for the study of sirtuin function as well as their potential therapeutic interest.
Cancer Cell published new progress about 380315-80-0. 380315-80-0 belongs to amides-buliding-blocks, auxiliary class Apoptosis,p53, name is N-((4-Acetamidophenyl)carbamothioyl)-4-(tert-butyl)benzamide, and the molecular formula is C20H23N3O2S, HPLC of Formula: 380315-80-0.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics