Hashimoto, Toru published the artcileIridium-Catalyzed [2+2+2] Cycloaddition of α,ω-Diynes with Cyanamides, Application In Synthesis of 2451-91-4, the publication is Advanced Synthesis & Catalysis (2015), 357(18), 3901-3916, database is CAplus.
The complex [Ir(cod)Cl]2/DPPF or rac-BINAP is an efficient catalyst for the [2+2+2] cycloaddition of α,ω-diynes with cyanamides. A wide range of cyanamides derived from secondary amines are good coupling partners for α,ω-diynes. The reaction of unsym. α,ω-diynes possessing two different internal alkyne moieties with cyanamides is regioselective. A competitive experiment showed that cyanamide is more reactive than nitrile. This higher reactivity of cyanamide than nitrile was analyzed based on d. functional theory (DFT) calculations at the B3LYP level.
Advanced Synthesis & Catalysis published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C15H14N2, Application In Synthesis of 2451-91-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics