Brunelle, Laura D. published the artcileComprehensive assessment of chemical residues in surface and wastewater using passive sampling, chemical, biological, and fish behavioral assays, Synthetic Route of 137862-53-4, the publication is Science of the Total Environment (2022), 154176, database is CAplus and MEDLINE.
Effluents from ten full-scale municipal wastewater treatment plants (WWTPs) that discharge into the Hudson River, surface waters, and wild-caught fish samples were analyzed using liquid chromatog. with tandem mass spectrometry (LC/MS/MS) to examine the influence of wastewater discharge on the concentrations of contaminants of emerging concern (CECs) and their ecol. impacts on fish. Anal. was based on targeted detection of 41 pharmaceuticals, and non-targeted anal. (suspect screening) of CECs. Biol. effects of treated WWTP effluents were assessed using a larval zebrafish (Danio rerio) swimming behavior assay. Concentrations of residues in surface waters were determined in grab samples and polar organic chem. integrative samplers (POCIS). In addition, vitellogenin peptides, used as biomarkers of endocrine disruption, were quantified using LC/MS/MS in the wild-caught fish plasma samples. Overall, 94 chem. residues were identified, including 63 pharmaceuticals, 10 industrial chems., and 21 pesticides. Eight targeted pharmaceuticals were detected in 100% of effluent samples with median detections of: bupropion (194 ng/L), carbamazepine (91 ng/L), ciprofloxacin (190 ng/L), citalopram (172 ng/L), desvenlafaxine (667 ng/L), iopamidol (3790 ng/L), primidone (86 ng/L), and venlafaxine (231 ng/L). Over 30 chem. residues were detected in wild-caught fish tissues. Notably, zebrafish larvae exposed to chem. extracts of effluents from 9 of 10 WWTPs, in at least one season, were significantly hyperactive. Vitellogenin expression in male or immature fish occurred 2.8 times more frequently in fish collected from the Hudson River as compared to a reference site receiving no direct effluent input. Due to the low concentrations of pharmaceuticals detected in effluents, it is likely that chems. other than pharmaceuticals measured are responsible for the behavioral changes observed The combined use of POCIS and non-target anal. demonstrated significant increase in the chem. coverage for CEC detection, providing a better insight on the impacts of WWTP effluents and agricultural practices on surface water quality.
Science of the Total Environment published new progress about 137862-53-4. 137862-53-4 belongs to amides-buliding-blocks, auxiliary class GPCR/G Protein,Angiotensin Receptor, name is (S)-2-(N-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid, and the molecular formula is C24H29N5O3, Synthetic Route of 137862-53-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics