Bogdanovic, Aleksandra published the artcileCharacterisation of twelve newly synthesised N-(substituted phenyl)-2-chloroacetamides with QSAR analysis and antimicrobial activity tests, Safety of 2-Chloroacetamide, the publication is Arhiv za Higijenu Rada i Toksikologiju (2021), 72(1), 70-79, database is CAplus and MEDLINE.
In this study we screened twelve newly synthesized N-(substituted phenyl)-2-chloroacetamides for antimicrobial potential relying on quant. structure-activity relationship (QSAR) anal. based on the available cheminformatics prediction models (Molinspiration, SwissADME, PreADMET, and PkcSM) and verified it through standard antimicrobial testing against Escherichia coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Candida albicans. Our compounds met all the screening criteria of Lipinski’s rule of five (Ro5) as well as Veber’s and Egan’s methods for predicting biol. activity. In antimicrobial activity tests, all chloroacetamides were effective against Gram-pos. S. aureus and MRSA, less effective against the Gram-neg. E. coli, and moderately effective against the yeast C. albicans. Our study confirmed that the biol. activity of chloroacetamides varied with the position of substituents bound to the Ph ring, which explains why some mols. were more effective against Gram-neg. than Gram-pos. bacteria or C. albicans. Bearing the halogenated p-substituted Ph ring, N-(4-chlorophenyl), N-(4-fluorophenyl), and N-(3-bromophenyl) chloroacetamides were among the most active thanks to high lipophilicity, which allows them to pass rapidly through the phospholipid bilayer of the cell membrane. They are the most promising compounds for further investigation, particularly against Gram-pos. bacteria and pathogenic yeasts.
Arhiv za Higijenu Rada i Toksikologiju published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Safety of 2-Chloroacetamide.
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