Albrecht, Brian K. published the artcileDiscovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase, Product Details of C8H9BFNO3, the publication is Journal of Medicinal Chemistry (2008), 51(10), 2879-2882, database is CAplus and MEDLINE.
Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small mols. that inhibit c-Met activity.
Journal of Medicinal Chemistry published new progress about 849833-86-9. 849833-86-9 belongs to amides-buliding-blocks, auxiliary class Fluoride,Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester, name is (3-Fluoro-4-(methylcarbamoyl)phenyl)boronic acid, and the molecular formula is C8H9BFNO3, Product Details of C8H9BFNO3.
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