One Pot Regioselective Synthesis of a Small Library of Dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles Rearrangement was written by Zhao, Yongmei;Dai, Qiaoling;Chen, Zhi;Zhang, Qihui;Bai, Yongcheng;Ma, Chen. And the article was included in ACS Combinatorial Science in 2013.Computed Properties of C14H11ClN2O3 The following contents are mentioned in the article:
A facile and efficient method has been developed for the synthesis of a small library of dibenzo[b,f][1,4]thiazepin-11(10H)-ones via Smiles rearrangement. Compounds were obtained in excellent isolated yields (70%-92%) under metal-free conditions. E.g., in presence of KOH in DMF, reaction of 2-chlorobenzamide derivative (I) with 2-BrC6H4SH gave 72% dibenzo[b,f][1,4]thiazepin-11(10H)-one derivative (II). More specifically, this transition metal-free process relates to an environmentally friendly, economical, and efficient method for preparing benzoic-fused seven-membered lactams. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Computed Properties of C14H11ClN2O3).
N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Computed Properties of C14H11ClN2O3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics