Growth Inhibitory Activity of a Bis-Benzimidazole-Bridged Arene Ruthenium Metalla-Rectangle and -Prism was written by Vajpayee, Vaishali;Lee, Sun mi;Park, Joeng Woo;Dubey, Abhishek;Kim, Hyunuk;Cook, Timothy R.;Stang, Peter J.;Chi, Ki-Whan. And the article was included in Organometallics in 2013.Synthetic Route of C12H10N4O2 The following contents are mentioned in the article:
Two new supramol. coordination complexes (SCCs) were obtained from the self-assembly of a new bis-benzimidazole bridged Ru acceptor, with dipyridyl and tripyridyl donors, resp. As part of a growing library of anticancer-active Ru-based SCCs, the self-assembled metalla-prism motif selectively showed high cytotoxicities relative to cisplatin for a series of cancer cell lines, with IC50 values as low as 8.41 μM for MCF7 cells, as determined from MTS assays. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Synthetic Route of C12H10N4O2).
N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Synthetic Route of C12H10N4O2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics