Column Chromatography-Free Solution-Phase Synthesis of a Natural Piper-Amide-like Compound Library was written by Kim, Sumin;Lim, Chaemin;Lee, Sukjin;Lee, Seokwoo;Cho, Hyunkyung;Lee, Joo-Youn;Shim, Dong Sup;Park, Hee Dong;Kim, Sanghee. And the article was included in ACS Combinatorial Science in 2013.Recommanded Product: 18836-52-7 The following contents are mentioned in the article:
We have achieved an efficient solution-phase parallel synthesis of a library of natural Piper-amide-like compounds from the bifunctional β-phosphono-N-hydroxy-succinimidyl ester intermediate. The primary important feature in our study is the construction of natural-product-like mols. through the adaptation of sophisticated organic reactions that create water-soluble byproducts for a chromatog.-free purification This simple and efficient method rapidly provides a combinatorial library of high yield and purity. The library was evaluated against GPCR targets to demonstrate its potential use as a tool for drug discovery and in chem. biol. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Recommanded Product: 18836-52-7).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Recommanded Product: 18836-52-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics