Increasing the selectivity of biologically active tetranuclear arene ruthenium assemblies was written by Gupta, Gajendra;Nowak-Sliwinska, Patrycja;Herrero, Noelia;Dyson, Paul J.;Therrien, Bruno. And the article was included in Journal of Organometallic Chemistry in 2015.Name: N1,N2-Di(pyridin-4-yl)oxalamide The following contents are mentioned in the article:
A series of arene ruthenium metalla-rectangles of general formula [(η6-p-cymene)4Ru4(μ4-embelin)2(μ2-N-N)2](CF3SO3)4 was prepared from the embelin-derived metalla-clip (η6-p-cymene)2Ru2(μ4-embelin)Cl2 (1), silver triflate and several linear ditopic N-ligands (N-N); pyrazine (prz), 4,4′-bipyridine (bpy), 1,2-bis(4-pyridyl)ethylene (bpe), 4,4′-azopyridine (azp) and di(pyridin-4-yl)oxalamide (bpo). The antiproliferative activity of these multinuclear arene ruthenium metalla-rectangles was evaluated in vitro on the human ovarian cancer cells A2780 and A2780cisR and on the noncancerous cell line HEK-293. Among these complexes, two rectangles, [(η6-p-cymene)4Ru4(μ4-embelin)2(μ2-bpy)2](CF3SO3)4 and [(η6-p-cymene)4Ru4(μ4-embelin)2(μ2-bpo)2](CF3SO3)4, display excellent activity and selectivity for cancer cells. This study involved multiple reactions and reactants, such as N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7Name: N1,N2-Di(pyridin-4-yl)oxalamide).
N1,N2-Di(pyridin-4-yl)oxalamide (cas: 53118-43-7) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Name: N1,N2-Di(pyridin-4-yl)oxalamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics