Isolation of melanin biosynthesis inhibitory compounds from the roots of Asarum sieboldii was written by Choi, Eun Hyang;Choi, Ji Young;Lee, Jong Gu;Oh, Joon Seok;Kim, Dong Chun;Lee, Hee Sang;Son, Jong Keun;Ryang, Son Ae;Kim, Jeong Ah;Lee, Seung Ho. And the article was included in Saengyak Hakhoechi in 2007.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide The following contents are mentioned in the article:
Eight compounds were isolated from the roots of Asarum sieboldii and their structures were identified as (±)-car-3-ene-2,5-dione, (-)-asarinin, (-)-sesamin, eucarvone, methyleugenol , γ-asarone, pellitorine and asarinol A by anal. of spectral data. Among them, (-)-asarinin showed the most potent inhibitory effect on melanogenesis, with inhibition rate of 66%. This study involved multiple reactions and reactants, such as (2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide).
(2E,4E)-N-Isobutyldeca-2,4-dienamide (cas: 18836-52-7) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are not in general accessible by the direct condensation of amines with carboxylic acids for two reasons: first, both components are readily deactivated by a transfer of a proton from the acid to the amine and second, the hydroxy unit on the carbonyl of the acid is a relatively poor leaving group. Nevertheless, the formation of five- and six-membered rings is often surprisingly simple provided that other factors can be brought into play to assist in the condensation.Quality Control of (2E,4E)-N-Isobutyldeca-2,4-dienamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics