A highly efficient copper-catalyzed method for the synthesis of 2-hydroxybenzamides in water was written by Balkrishna, Shah Jaimin;Kumar, Sangit. And the article was included in Synthesis in 2012.Reference of 83909-69-7 The following contents are mentioned in the article:
An efficient copper-catalyzed synthetic method for the preparation of 2-hydroxybenzamides was described from 2-chlorobenzamide substrates using CuI/1,10-phenanthroline and a base, KOH, in neat water. By using this reaction, a series of 2-hydroxybenzamides with functional groups, such as F, Cl, I, MeO, amide, and alc., were obtained in 33-96% yield. Other aromatic 2-chloroarylamides, such as naphthalene, pyridine, and thiophene, are equally compatible to the reaction. It is proposed that the reaction proceeds via formation of a copper-amide complex, which may facilitate the hydroxylation in water. Simple purification procedure and convenience of employing low-cost reagents in neat water make this method practical and economical for the synthesis of 2-hydroxybenzamides. This study involved multiple reactions and reactants, such as N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7Reference of 83909-69-7).
N-Benzyl-2-chloro-5-nitrobenzamide (cas: 83909-69-7) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Reference of 83909-69-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics