Wang, Meng published the artcileDifferential contribution of BLT1 and BLT2 to leukotriene B4-induced human NK cell cytotoxicity and migration, Related Products of amides-buliding-blocks, the publication is Mediators of Inflammation (2015), 389849/1-389849/14, database is CAplus and MEDLINE.
Accumulating evidence indicates that leukotriene B4 (LTB4) via its receptors BLT1 and/or BLT2 (BLTRs) could have an important role in regulating infection, tumor progression, inflammation, and autoimmune diseases. In the present study, we showed that LTB4 not only augments cytotoxicity by NK cells but also induces their migration. We found that approx. 30% of fresh NK cells express BLT1, 36% express BLT2, and 15% coexpress both receptors.The use of selective BLTR antagonists indicated that BLT1 was involved in both LTB4-induced migration and cytotoxicity, whereas BLT2 was involved exclusively in NK cell migration, but only in response to higher concentrations of LTB4. BLT1 and BLT2 expression increased after activation of NK cells with IL-2 and IL-15.These changes of BLTR expression by cytokines were reflected in enhanced NK cell responses to LTB4. Our findings suggest that BLT1 and BLT2 play differential roles in LTB4-induced modulation of NK cell activity.
Mediators of Inflammation published new progress about 321673-30-7. 321673-30-7 belongs to amides-buliding-blocks, auxiliary class Immunology/Inflammation,Scavenger receptor, name is [(2-Hexylcyclopentylidene)amino]thiourea, and the molecular formula is C5H5F3O2, Related Products of amides-buliding-blocks.
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