Shcherbakov, Nikolay V. published the artcileHetero-Tetradehydro-Diels-Alder Cycloaddition of Enynamides and Cyanamides: Gold-Catalyzed Generation of Diversely Substituted 2,6-Diaminopyridines, Synthetic Route of 2451-91-4, the publication is Journal of Organic Chemistry (2021), 86(10), 7218-7228, database is CAplus and MEDLINE.
The reaction proceeds under very mild conditions (DCM, rt) with high functional group tolerance. The obtained 2,6-diaminopyridines I and II represent a useful synthetic platform with an easily modulated substitution pattern for subsequent functionalizations of both the pyridine core and the N-substituents. Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides R1CH=C(R2)CCN(R3)R4 [R1 = C6H5, 2-thienyl, 1-naphthyl, etc.; R2 = H, Me; R3 = Me, Ph, Bn, Ts; R4 = 4-MeC6H4S(O)2, MeS(O)2, 4-FC6H4S(O)2, CH2CH=CH2, 2-(2H-1,3-benzodioxol-5-yl)ethyl; R3R4 = -C(O)O(CH2)2-] and cyanamides R5R6NCN (R5 = Me, Et, Bn, Ph; R6 = Me, Et, Bn, Ph; R5R6 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-) and 3,4-dihydro-2(1H)-Isoquinolinecarbonitrile comprises an efficient route to diversely substituted 2,6-diaminopyridines I and II (yields up to 99%).
Journal of Organic Chemistry published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C18H24N6O6S4, Synthetic Route of 2451-91-4.
Referemce:
https://en.wikipedia.org/wiki/Amide,
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