Shcherbakov, Nikolay V. published the artcileRedox-Neutral and Atom-Economic Route to β-Carbolines via Gold-Catalyzed [4 + 2] Cycloaddition of Indolylynamides and Cyanamides, Safety of N,N-Dibenzylcyanamide, the publication is Journal of Organic Chemistry (2021), 86(24), 17804-17815, database is CAplus and MEDLINE.
Gold(I)-catalyzed [4 + 2] cycloaddition of indolylynamides I (R = Ts, Boc; R1 = R2 = H BnO; R3 = tosyl, mesyl, brosyl, etc.; R4 = Me, cyclopropyl, benzyl, etc.; R3R4 = -C(O)O(CH2)2-) and cyanamides (aminonitriles) R5CN [R5 = diethylamino, methylphenylamino, pyrrolidino, etc.] is an efficient redox-neutral and atom-economic route to diversely substituted 1,3-diamino-α-carbolines II. The protocol operates under mild conditions (Ph3PAuNTf2 5 mol%, DCE, 60°C) with a good tolerance to functional groups (23 examples and yields up to 98%). The obtained α-carboline systems represent a versatile synthetic platform with modifiable substituents for successive functionalizations. Control experiments indicate the crucial role of both the nature of reactants and the identity of employed catalysts in the developed cycloaddition
Journal of Organic Chemistry published new progress about 2451-91-4. 2451-91-4 belongs to amides-buliding-blocks, auxiliary class Nitrile,Amine,Benzene, name is N,N-Dibenzylcyanamide, and the molecular formula is C14H18BNO2, Safety of N,N-Dibenzylcyanamide.
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