Neta, Pedatsur published the artcileUnexpected peaks in tandem mass spectra due to reaction of product ions with residual water in mass spectrometer collision cells, Product Details of C10H14N2O, the publication is Rapid Communications in Mass Spectrometry (2014), 28(23), 2645-2660, database is CAplus and MEDLINE.
Certain product ions in electrospray ionization tandem mass spectrometry react with residual water in the collision cell. This reaction often gives ions that cannot be formed directly from the precursor ions, and this complicates the mass spectra and may distort MRM (multiple reaction monitoring) results. Various drugs, pesticides, metabolites, and other compounds were dissolved in acetonitrile/water/formic acid and studied by electrospray ionization mass spectrometry to record their MS2 and MSn spectra in several mass spectrometers (QqQ, QTOF, IT, and Orbitrap HCD). Certain product ions react with residual water in collision cells. The reaction was confirmed by MSn studies and the rate of reaction was determined in the IT instrument using zero collision energy and variable activation times. Examples of product ions reacting with water include Ph and certain substituted Ph cations, benzoyl-type cations formed from protonated folic acid and similar compounds by loss of the glutamate moiety, product ions formed from protonated cyclic siloxanes by loss of methane, product ions formed from organic phosphates, and certain neg. ions. The reactions of product ions with residual water varied greatly in their rate constant and in the extent of reaction (due to isomerization). Thus, various types of product ions react with residual water in mass spectrometer collision cells. As a result, tandem mass spectra may contain unexplained peaks and MRM results may be distorted by the occurrence of such reactions. These often unavoidable reactions must be taken into account when annotating peaks in tandem mass spectra and when interpreting MRM results.
Rapid Communications in Mass Spectrometry published new progress about 530-40-5. 530-40-5 belongs to amides-buliding-blocks, auxiliary class Pyridine,Amine,Amide, name is N,N-Diethylisonicotinamide, and the molecular formula is C10H14N2O, Product Details of C10H14N2O.
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https://en.wikipedia.org/wiki/Amide,
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