Matsunuma, Satoru published the artcileHigh concentration of oxaliplatin may be a risk factor for vascular pain, SDS of cas: 169590-42-5, the publication is Journal of Clinical Pharmacy and Therapeutics (2022), 47(4), 462-468, database is CAplus and MEDLINE.
Oxaliplatin (L-OHP) is an antineoplastic agent that frequently causes vascular pain. However, the risk factors for vascular pain are unclear, and prevention methods have not been established. We retrospectively investigated patients who were treated with L-OHP to examine the influence of patient characteristics and concomitant analgesic use on the incidence of vascular pain. We collected information about the presence or absence of vascular pain, age, sex, treatment dose and analgesic use of patients who received L-OHP at Tokyo Medical University Hachioji Medical Center. We analyzed the relevance of each factor between the vascular pain onset and non-onset groups. Thirty-two patients (average age: 68.6 years; 69.8% and 30.2% men and women, resp.) were classified into the vascular pain onset (n = 64) and non-onset groups (n = 68). The multivariate logistic regression anal. revealed that L-OHP concentration (>358.5 mg/L) was an independent determinant of vascular pain development (odds ratio: 2.422, 95% CI: 1.117-5.252). Intergroup differences in age, sex, body mass index, non-steroidal anti-inflammatory drug use, and underlying pain from cancer and other comorbidities were not significant. High L-OHP concentration was identified as a significant risk factor for L-OHP-induced vascular pain. Our results indicate that the dilution of L-OHP may reduce the incidence of vascular pain.
Journal of Clinical Pharmacy and Therapeutics published new progress about 169590-42-5. 169590-42-5 belongs to amides-buliding-blocks, auxiliary class Sulfamide,Immunology/Inflammation,COX, name is 4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide, and the molecular formula is C17H14F3N3O2S, SDS of cas: 169590-42-5.
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