Krivokolysko, D. S. published the artcileSynthesis, Structure, and Analgesic Activity of 4-(5-Cyano-{4-(fur-2-yl)-1,4-dihydropyridin-3-yl}carboxamido)benzoic Acids Ethyl Esters, Synthetic Route of 79-07-2, the publication is Russian Journal of General Chemistry (2021), 91(12), 2588-2605, database is CAplus.
A series of new hybrid mols. containing fragments of anesthesin and 4-(2-furyl)-1,4-dihydronicotinonitrile have been obtained starting from diketene, Et 4-aminobenzoate, cyanothioacetamide, and furfural. The obtained compounds have been investigated for the analgesic activity in vivo (rats) in the orofacial trigeminal pain and acetic acid induced writhing tests. The compounds exhibiting analgesic effect superior to that of the reference drug (metamizole sodium) have been revealed. Mol. docking has been performed for the considered compounds with respect to a wide range of protein targets, including cyclooxygenases COX-1 and COX-2.
Russian Journal of General Chemistry published new progress about 79-07-2. 79-07-2 belongs to amides-buliding-blocks, auxiliary class Chloride,Amine,Aliphatic hydrocarbon chain,Amide,Inhibitor, name is 2-Chloroacetamide, and the molecular formula is C2H4ClNO, Synthetic Route of 79-07-2.
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